Current therapies for ANCA-associated vasculitis.
Annu Rev Med
; 66: 227-40, 2015.
Article
in En
| MEDLINE
| ID: mdl-25341007
ABSTRACT
The ANCA-associated vasculitides, granulomatosis with polyangiitis (GPA, formerly Wegener's), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA, formerly Churg-Strauss), are a group of multisystem autoimmune diseases characterized by necrotizing small- to medium-vessel vasculitis and the presence of anti-neutrophil cytoplasmic antibodies. Current therapeutic strategies consist of glucocorticoids in conjunction with either conventional or biologic agents for both induction of remission and remission maintenance. Treatment goals include reducing toxicity of induction therapy, preventing disease relapse, and limiting overall accrual of both disease-related damage and treatment-related morbidity. Future research directions include investigation of the optimal duration and frequency of maintenance therapy as well as development of targeted therapeutic agents, which is enhanced by emerging insights into disease pathogenesis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasma Exchange
/
Antirheumatic Agents
/
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
/
Glucocorticoids
/
Immunosuppressive Agents
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Annu Rev Med
Year:
2015
Document type:
Article