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LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory.
Beccano-Kelly, Dayne A; Volta, Mattia; Munsie, Lise N; Paschall, Sarah A; Tatarnikov, Igor; Co, Kimberley; Chou, Patrick; Cao, Li-Ping; Bergeron, Sabrina; Mitchell, Emma; Han, Heather; Melrose, Heather L; Tapia, Lucia; Raymond, Lynn A; Farrer, Matthew J; Milnerwood, Austen J.
Affiliation
  • Beccano-Kelly DA; Centre for Applied Neurogenetics, Brain Research Centre.
  • Volta M; Centre for Applied Neurogenetics, Brain Research Centre.
  • Munsie LN; Centre for Applied Neurogenetics, Brain Research Centre.
  • Paschall SA; Centre for Applied Neurogenetics, Brain Research Centre.
  • Tatarnikov I; Centre for Applied Neurogenetics, Brain Research Centre.
  • Co K; Centre for Applied Neurogenetics, Brain Research Centre.
  • Chou P; Centre for Applied Neurogenetics, Brain Research Centre.
  • Cao LP; Centre for Applied Neurogenetics, Brain Research Centre.
  • Bergeron S; Centre for Applied Neurogenetics, Brain Research Centre.
  • Mitchell E; Centre for Applied Neurogenetics, Brain Research Centre.
  • Han H; Centre for Applied Neurogenetics, Brain Research Centre.
  • Melrose HL; Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
  • Tapia L; Centre for Applied Neurogenetics, Brain Research Centre.
  • Raymond LA; Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, Canada V6T 2B5.
  • Farrer MJ; Centre for Applied Neurogenetics, Brain Research Centre, Department of Medical Genetics.
  • Milnerwood AJ; Centre for Applied Neurogenetics, Division of Neurology, Brain Research Centre, amilnerwood@can.ubc.ca.
Hum Mol Genet ; 24(5): 1336-49, 2015 Mar 01.
Article in En | MEDLINE | ID: mdl-25343991
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Dopamine / Protein Serine-Threonine Kinases / Neostriatum / Memory / Motor Activity Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2015 Document type: Article Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Dopamine / Protein Serine-Threonine Kinases / Neostriatum / Memory / Motor Activity Limits: Animals Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2015 Document type: Article Country of publication: Reino Unido