Novel synthesis of the ABC rings of solanoeclepin A.
Org Lett
; 16(22): 5948-51, 2014 Nov 21.
Article
in En
| MEDLINE
| ID: mdl-25376022
ABSTRACT
A stereocontrolled synthesis of the ABC rings of solanoeclepin A has been achieved. The seven-membered ring B was synthesized by an intramolecular Prins-ene reaction between an aldehyde and an enyne-dicobalthexacarbonyl complex. The acetylene in this synthesis plays multiple roles to join the A and C rings, to allow stereoselective cyclization via dicobalthexacarbonyl complexation, and to facilitate Nicholas cation stabilization followed by deprotonation to form an endo-cyclic olefin (Nicholas-Prins cyclization).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bridged-Ring Compounds
/
Hexanes
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2014
Document type:
Article
Affiliation country:
Taiwán