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A lack of confirmation with alternative assays questions the validity of IL-17A expression in human neutrophils using immunohistochemistry.
Tamarozzi, Francesca; Wright, Helen L; Thomas, Huw B; Edwards, Steven W; Taylor, Mark J.
Affiliation
  • Tamarozzi F; Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK.
  • Wright HL; Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
  • Thomas HB; Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
  • Edwards SW; Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
  • Taylor MJ; Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK. Electronic address: Mark.Taylor@lstmed.ac.uk.
Immunol Lett ; 162(2 Pt B): 194-8, 2014 Dec.
Article in En | MEDLINE | ID: mdl-25445614
ABSTRACT
We identified IL-17A-positive neutrophils in Wolbachia-positive Onchocerca volvulus nodules using an antibody that has previously reported IL-17A-positive neutrophils in several inflammatory conditions. However, we could not detect IL-17A using a range of alternative assays. Our data question the IL-17A antibody specificity and the ability of human neutrophils to express IL-17A.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Onchocerciasis / Antibodies, Helminth / Onchocerca volvulus / Interleukin-17 / Neutrophils Type of study: Clinical_trials Limits: Animals / Female / Humans / Male Language: En Journal: Immunol Lett Year: 2014 Document type: Article Affiliation country: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Onchocerciasis / Antibodies, Helminth / Onchocerca volvulus / Interleukin-17 / Neutrophils Type of study: Clinical_trials Limits: Animals / Female / Humans / Male Language: En Journal: Immunol Lett Year: 2014 Document type: Article Affiliation country: Reino Unido