A mechanism-based inactivator of glycoside hydrolases involving formation of a transient non-classical carbocation.

Chakladar, Saswati; Wang, Yi; Clark, Thomas; Cheng, Lydia; Ko, Shirley; Vocadlo, David J; Bennet, Andrew J

Chakladar, Saswati; Wang, Yi; Clark, Thomas; Cheng, Lydia; Ko, Shirley; Vocadlo, David J; Bennet, Andrew J.

Affiliation

Chakladar S; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Wang Y; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Clark T; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Cheng L; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Ko S; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Vocadlo DJ; 1] Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6 [2] Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Bennet AJ; Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.

Nat Commun ; 5: 5590, 2014 Dec 05.

Article in En | MEDLINE | ID: mdl-25475952

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bacterial Proteins / Thermotoga maritima / Enzyme Inhibitors / Galactose / Galactosidases Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2014 Document type: Article

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