Nutrition affects Sertoli cell function but not Sertoli cell numbers in sexually mature male sheep.
Reprod Fertil Dev
; 2014 Dec 17.
Article
in En
| MEDLINE
| ID: mdl-25515817
We tested whether the reversible effects of nutrition on spermatogenesis in sexually mature sheep were mediated by Sertoli cells. Rams were fed with diets designed to achieve a 10% increase (High), no change (Maintenance) or a 10% decrease (Low) in body mass after 65 days. At the end of treatment, testes were lighter in the Low than the High group (PP<0.05) in the expression of seven Sertoli cell-specific genes. Under-nutrition appeared to reverse cellular differentiation leading to disruption of tight-junction morphology. In conclusion, in sexually mature sheep, reversible reductions in testis mass and spermatogenesis caused by under-nutrition were associated with impairment of basic aspects of Sertoli cell function but not with changes in the number of Sertoli cells.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Reprod Fertil Dev
Journal subject:
MEDICINA REPRODUTIVA
Year:
2014
Document type:
Article
Country of publication:
Australia