Targeting of γ-tubulin complexes to microtubule organizing centers: conservation and divergence.
Trends Cell Biol
; 25(5): 296-307, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25544667
ABSTRACT
Organisms with closed or open mitosis have differentially evolved various gamma-tubulin complex (γ-TuC) recruiting factors to organize diverse cellular microtubule (MT) arrays, including the mitotic spindle. γ-TuC recruiting factors not only target the γ-TuC to MT nucleation sites, but also regulate MT nucleation activity by generating the template for MT nucleation or promoting the MT nucleation activity of pre-existing γ-tubulin ring complexes (γ-TuRCs). Here we outline the current understanding of MT nucleator assembly and its regulation by γ-tubulin small complex (γ-TuSC) receptors. Moreover, we discuss the emergence of γ-TuC recruiting factors through evolution with augmented complexity and diversity and propose a hypothesis to account for the evolution of these factors in cooperative spindle assembly.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tubulin
/
Microtubule-Organizing Center
/
Microtubules
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Cell Biol
Year:
2015
Document type:
Article