Depsipeptide companeramides from a Panamanian marine cyanobacterium associated with the coibamide producer.
J Nat Prod
; 78(3): 413-20, 2015 Mar 27.
Article
in En
| MEDLINE
| ID: mdl-25562664
ABSTRACT
Two new cyclic depsipeptides, companeramides A (1) and B (2), have been isolated from the phylogenetically characterized cyanobacterial collection that yielded the previously reported cancer cell toxin coibamide A (collected from Coiba Island, Panama). The planar structures of the companeramides, which contain 3-amino-2-methyl-7-octynoic acid (Amoya), hydroxy isovaleric acid (Hiva), and eight α-amino acid units, were established by NMR spectroscopy and mass spectrometry. The absolute configuration of each companeramide was assigned using a combination of Marfey's methodology and chiral-phase HPLC analysis of complete and partial hydrolysis products compared to commercial and synthesized standards. Companeramides A (1) and B (2) showed high nanomolar in vitro antiplasmodial activity but were not overtly cytotoxic to four human cancer cell lines at the doses tested.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cyanobacteria
/
Depsipeptides
/
Antineoplastic Agents
Type of study:
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
America central
/
Panama
Language:
En
Journal:
J Nat Prod
Year:
2015
Document type:
Article
Affiliation country:
Estados Unidos