Geminal dihalogen isosteric replacement in hydrated AI-2 affords potent quorum sensing modulators.
Chem Commun (Camb)
; 51(13): 2617-20, 2015 Feb 14.
Article
in En
| MEDLINE
| ID: mdl-25573337
ABSTRACT
Hydrated carbonyl groups in AI-2, a quorum sensing autoinducer, make key hydrogen bonding interactions in the binding site of LsrR (a transcriptional regulator). This can be recapitulated with geminal dibromides, via halogen bonding. Geminal dihalogens represent interesting isosteric replacements for hydrated carbonyls in ligands and are currently under-utilized in ligand design.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quorum Sensing
/
Homoserine
/
Lactones
Type of study:
Prognostic_studies
Language:
En
Journal:
Chem Commun (Camb)
Journal subject:
QUIMICA
Year:
2015
Document type:
Article
Affiliation country:
Estados Unidos