Antileishmanial activity of quinazoline derivatives: synthesis, docking screens, molecular dynamic simulations and electrochemical studies.
Eur J Med Chem
; 92: 314-31, 2015 Mar 06.
Article
in En
| MEDLINE
| ID: mdl-25576738
ABSTRACT
A series of quinazoline-2,4,6-triamine were synthesized and evaluated in vitro against Leishmania mexicana. Among them, N(6)-(ferrocenmethyl)quinazolin-2,4,6-triamine (H2) showed activity on promastigotes and intracellular amastigotes, as well as low cytotoxicity in mammalian cells. Docking and electrochemical studies showed the importance of both the ferrocene and the heterocyclic nucleus to the observed activity. H2 is readily oxidized electrochemically, indicating that the mechanism of action probably involves redox reactions.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leishmania mexicana
/
Electrochemical Techniques
/
Molecular Dynamics Simulation
/
Molecular Docking Simulation
/
Antiprotozoal Agents
Limits:
Animals
Language:
En
Journal:
Eur J Med Chem
Year:
2015
Document type:
Article
Affiliation country:
México