Usefulness of antibodies and minor salivary gland biopsy in the study of sicca syndrome in daily clinical practice.
Reumatol Clin
; 11(3): 156-60, 2015.
Article
in En
| MEDLINE
| ID: mdl-25579246
ABSTRACT
OBJECTIVES:
To assess the association between histologic findings in the minor salivary gland biopsy (MSGB) and anti La (La/SS-B)y antiRo antibodies (Ro/SS-A), antinuclear antibodies (ANA) and Rheumatoid Factor (RF),and compare the value of the latter as diagnostic tests with MSGB, considered as the gold standard. MATERIAL ANDMETHOD:
Patients with suspected Primary Sjögren Syndrome (PSS) referred for MSGB were included. Antibody measurements were performed. Grade III and IV biopsy results were considered positive.RESULTS:
Two hundred and eighteen (218) patients were included, 95% females, with a median age of 54 years and 12 months median duration of sicca symptoms. 36 of the biopsies were positive. 33% of patients had positive anti Ro/SS-A anti La/SS-B antibodies, 62% had positive ANA, and 31% positive RF. A statistically significant association was found between MSGB and anti Ro/SS-A anti La/SS-B, ANA and RF. ANA were the most sensitive antibodies (84%. 95% CI 75- 92), and the most specific were Anti Ro/ SS-A and/or anti La/ SS-B (78%. 95% CI 71-85) and RF (78%. 95% CI 69-87).CONCLUSION:
On PSS clinical suspicion, anti Ro/ SS-A y anti La/ SS-B antibodies have a great value to achieve the diagnosis, with MSGB useful for diagnosis of seronegative patients. The results also suggest the importance of ANA and RF for PSS classification.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rheumatoid Factor
/
Salivary Glands, Minor
/
Sjogren's Syndrome
/
Antibodies, Antinuclear
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Reumatol Clin
Year:
2015
Document type:
Article
Publication country:
ES
/
ESPANHA
/
ESPAÑA
/
SPAIN