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PDE4 inhibition reduces neointima formation and inhibits VCAM-1 expression and histone methylation in an Epac-dependent manner.
Lehrke, Michael; Kahles, Florian; Makowska, Anna; Tilstam, Pathricia V; Diebold, Sebastian; Marx, Judith; Stöhr, Robert; Hess, Katharina; Endorf, Elizabeth B; Bruemmer, Dennis; Marx, Nikolaus; Findeisen, Hannes M.
Affiliation
  • Lehrke M; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: mlehrke@ukaachen.de.
  • Kahles F; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: florian.kahles@rwth-aachen.de.
  • Makowska A; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: amakowska@ukaachen.de.
  • Tilstam PV; Institute of Molecular Cardiovascular Research, RWTH Aachen University, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: ptilstam@ukaachen.de.
  • Diebold S; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: sdiebold@ukaachen.de.
  • Marx J; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: judith.marx@rwth-aachen.de.
  • Stöhr R; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: rstoehr@ukaachen.de.
  • Hess K; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: khess@ukaachen.de.
  • Endorf EB; Division of Cardiovascular Medicine, Gill Heart Institute, Saha Cardiovascular Research Center, University of Kentucky, College of Medicine, 741 South Limestone, Lexington, KY 40536-0509, USA. Electronic address: brydenheywood@uky.edu.
  • Bruemmer D; Division of Cardiovascular Medicine, Gill Heart Institute, Saha Cardiovascular Research Center, University of Kentucky, College of Medicine, 741 South Limestone, Lexington, KY 40536-0509, USA. Electronic address: dennis.bruemmer@uky.edu.
  • Marx N; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: nmarx@ukaachen.de.
  • Findeisen HM; Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany; Department of Cardiology and Angiology, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149 Muenster, Germany. Electronic address: hannes.findeisen@ukmuenster.de.
J Mol Cell Cardiol ; 81: 23-33, 2015 Apr.
Article in En | MEDLINE | ID: mdl-25640159
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Vascular Cell Adhesion Molecule-1 / Guanine Nucleotide Exchange Factors / Cyclic Nucleotide Phosphodiesterases, Type 4 / Vascular System Injuries / Neointima / Phosphodiesterase 4 Inhibitors / Aminopyridines Language: En Journal: J Mol Cell Cardiol Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzamides / Vascular Cell Adhesion Molecule-1 / Guanine Nucleotide Exchange Factors / Cyclic Nucleotide Phosphodiesterases, Type 4 / Vascular System Injuries / Neointima / Phosphodiesterase 4 Inhibitors / Aminopyridines Language: En Journal: J Mol Cell Cardiol Year: 2015 Document type: Article