Lack of Hypophagia in CB1 Null Mice is Associated to Decreased Hypothalamic POMC and CART Expression.
Int J Neuropsychopharmacol
; 18(9)2015 Feb 05.
Article
in En
| MEDLINE
| ID: mdl-25655433
ABSTRACT
BACKGROUND:
Cumulative data indicate that the endocannabinoid system plays a major role in feeding behavior and energy balance. Genetic silencing of cannabinoid receptor type 1 (CB1) reduces body weight gain, independently of food intake.METHODS:
In this work, we investigated whether the hypothalamic neuropeptide expression pattern supports the absence of the anorexigenic response observed under constitutive CB1 ablation, by using neuronal CB1 conditional null mice (CamK-CB1-KO) and whole body CB1 null mice (CB1-KO).RESULTS:
Our data showed that both CB1 null models display a marked decrease in proopiomelanocortin (POMC) and cocaine-amphetamine-regulated transcript (CART) expression in the arcuate nucleus of the hypothalamus (ARC).CONCLUSIONS:
This evidence suggests that a lack of hypophagia is associated with the suppression of ARC anorexigenic neuropeptides and that behavioral changes in food intake (or lack thereof) after constitutive CB1 ablation are likely mediated by impaired melanocortin and CART signaling in the hypothalamus.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arcuate Nucleus of Hypothalamus
/
Pro-Opiomelanocortin
/
Anorexia
/
Receptor, Cannabinoid, CB1
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Feeding Behavior
/
Nerve Tissue Proteins
Type of study:
Risk_factors_studies
Limits:
Animals
Language:
En
Journal:
Int J Neuropsychopharmacol
Journal subject:
NEUROLOGIA
/
PSICOFARMACOLOGIA
Year:
2015
Document type:
Article