Correlation of circulating betatrophin concentrations with insulin secretion capacity, evaluated by glucagon stimulation tests.
Diabet Med
; 32(5): 653-6, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-25655786
ABSTRACT
AIM:
To investigate the relationship between plasma betatrophin concentrations and insulin secretion capacity in people with Type 2 diabetes.METHODS:
Glucagon stimulation tests (1 mg) were performed in 70 people with Type 2 diabetes after an overnight fast. Plasma betatrophin concentrations were measured using an enzyme-linked immunosorbent assay. Insulin secretion capacity was evaluated by measuring increments of C-peptide concentration in response to glucagon stimulation, and creatinine clearance was determined by comparing creatinine concentrations in serum and 24-h urine samples.RESULTS:
Plasma betatrophin concentrations were positively correlated with duration of Type 2 diabetes (r = 0.34, P = 0.003), and negatively correlated with increments of C-peptide concentration (r = 0.37, P = 0.001) and creatinine clearance (r = 0.37, P = 0.001). The correlation with increments of C-peptide concentration remained significant after adjustment for age and duration of Type 2 diabetes (r = 0.25, P = 0.037). Multivariate analysis identified age and increments of C-peptide concentration as independent factors associated with plasma betatrophin levels.CONCLUSION:
Plasma betatrophin levels inversely correlate with insulin secretion capacity, suggesting that betatrophin levels are regulated by insulin secretion capacity in humans.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glucagon
/
Peptide Hormones
/
Diabetes Mellitus, Type 2
/
Insulin-Secreting Cells
/
Insulin
Type of study:
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Diabet Med
Journal subject:
ENDOCRINOLOGIA
Year:
2015
Document type:
Article
Affiliation country:
Japón