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Tetrahydroisoquinolines affect the whole-cell phenotype of Mycobacterium tuberculosis by inhibiting the ATP-dependent MurE ligase.
Guzman, Juan D; Pesnot, Thomas; Barrera, Diana A; Davies, Heledd M; McMahon, Eleanor; Evangelopoulos, Dimitrios; Mortazavi, Parisa N; Munshi, Tulika; Maitra, Arundhati; Lamming, Eleanor D; Angell, Richard; Gershater, Markus C; Redmond, Joanna M; Needham, Deborah; Ward, John M; Cuca, Luis E; Hailes, Helen C; Bhakta, Sanjib.
Affiliation
  • Guzman JD; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Pesnot T; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
  • Barrera DA; Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia.
  • Davies HM; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • McMahon E; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Evangelopoulos D; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Mortazavi PN; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Munshi T; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Maitra A; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK.
  • Lamming ED; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
  • Angell R; Drug Discovery Group, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
  • Gershater MC; The Advanced Centre for Biochemical Engineering, University College London, Gordon Street, London WC1H 0AH, UK.
  • Redmond JM; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Needham D; Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK.
  • Ward JM; Drug Discovery Group, UCL School of Pharmacy, 29-39 Brunswick Square, London WC1N 1AX, UK.
  • Cuca LE; Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Carrera 30 No. 45-03, Bogotá, Colombia.
  • Hailes HC; Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK.
  • Bhakta S; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK s.bhakta@bbk.ac.uk sanjib.bhakta@ucl.ac.uk.
J Antimicrob Chemother ; 70(6): 1691-703, 2015.
Article in En | MEDLINE | ID: mdl-25656411
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Bacterial Proteins / Tetrahydroisoquinolines / Enzyme Inhibitors / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: J Antimicrob Chemother Year: 2015 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Bacterial Proteins / Tetrahydroisoquinolines / Enzyme Inhibitors / Mycobacterium tuberculosis / Antitubercular Agents Language: En Journal: J Antimicrob Chemother Year: 2015 Document type: Article Affiliation country: Reino Unido Country of publication: Reino Unido