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Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.
Chattopadhyay, Shrikanta; Stewart, Alison L; Mukherjee, Siddhartha; Huang, Cherrie; Hartwell, Kimberly A; Miller, Peter G; Subramanian, Radhika; Carmody, Leigh C; Yusuf, Rushdia Z; Sykes, David B; Paulk, Joshiawa; Vetere, Amedeo; Vallet, Sonia; Santo, Loredana; Cirstea, Diana D; Hideshima, Teru; Dancík, Vlado; Majireck, Max M; Hussain, Mahmud M; Singh, Shambhavi; Quiroz, Ryan; Iaconelli, Jonathan; Karmacharya, Rakesh; Tolliday, Nicola J; Clemons, Paul A; Moore, Malcolm A S; Stern, Andrew M; Shamji, Alykhan F; Ebert, Benjamin L; Golub, Todd R; Raje, Noopur S; Scadden, David T; Schreiber, Stuart L.
Affiliation
  • Chattopadhyay S; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic ad
  • Stewart AL; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Mukherjee S; Department of Medicine and Irving Cancer Research Center, Columbia University School of Medicine, New York, NY 10032, USA.
  • Huang C; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Hartwell KA; Cancer Program, Broad Institute, Cambridge, MA 02142, USA.
  • Miller PG; Harvard Medical School, Boston, MA 02115, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Subramanian R; Chemistry and Cell Biology, Rockefeller University, New York, NY 10065, USA.
  • Carmody LC; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Yusuf RZ; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Sykes DB; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Paulk J; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA.
  • Vetere A; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Vallet S; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Santo L; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Cirstea DD; Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Hideshima T; Dana-Farber Cancer Institute, Boston, MA 02115, USA.
  • Dancík V; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Majireck MM; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA.
  • Hussain MM; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute, Cambridge, MA 02142, USA.
  • Singh S; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA.
  • Quiroz R; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Iaconelli J; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Karmacharya R; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Schizophrenia and Bipolar Disorder Program, McLean Hospital, Belmont, MA 02478, US
  • Tolliday NJ; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Clemons PA; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Moore MAS; Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Stern AM; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Shamji AF; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA.
  • Ebert BL; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Division of Hematology, Brigham and Women's Hospital, Boston, MA 02115, USA.
  • Golub TR; Cancer Program, Broad Institute, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Howard Hughes Medical Institute, Broad Institute, Cambridge, MA 02142, USA.
  • Raje NS; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA.
  • Scadden DT; Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard University, Cambridge, MA 02138, USA.
  • Schreiber SL; Center for the Science of Therapeutics / Center for the Development of Therapeutics, Broad Institute, Cambridge, MA 02142, USA; Harvard University, Cambridge, MA 02138, USA; Howard Hughes Medical Institute, Broad Institute, Cambridge, MA 02142, USA. Electronic address: stuart_schreiber@harvard.edu.
Cell Rep ; 10(5): 755-770, 2015 Feb 10.
Article in En | MEDLINE | ID: mdl-25660025
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Cell Rep Year: 2015 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Cell Rep Year: 2015 Document type: Article Country of publication: Estados Unidos