Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory.

Li, P; Rial, D; Canas, P M; Yoo, J-H; Li, W; Zhou, X; Wang, Y; van Westen, G J P; Payen, M-P; Augusto, E; Gonçalves, N; Tomé, A R; Li, Z; Wu, Z; Hou, X; Zhou, Y; IJzerman, A P; PIJzerman, Ad; Boyden, E S; Cunha, R A; Qu, J; Chen, J-F

Li, P; Rial, D; Canas, P M; Yoo, J-H; Li, W; Zhou, X; Wang, Y; van Westen, G J P; Payen, M-P; Augusto, E; Gonçalves, N; Tomé, A R; Li, Z; Wu, Z; Hou, X; Zhou, Y; IJzerman, A P; PIJzerman, Ad; Boyden, E S; Cunha, R A; Qu, J; Chen, J-F.

Affiliation

Li P; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Rial D; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
Canas PM; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Yoo JH; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Li W; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Zhou X; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Wang Y; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
van Westen GJ; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
Payen MP; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Augusto E; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.
Gonçalves N; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Tomé AR; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Li Z; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Wu Z; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Hou X; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
Zhou Y; CNC - Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal.
IJzerman AP; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
PIJzerman A; School of Optometry and Ophthalmology and Eye Hospital, Wenzhou Medical College Wenzhou, Zhejiang, China.
Boyden ES; Department of Neurology and Pharmacology, Boston University School of Medicine, Boston, MA, USA.
Cunha RA; Molecular Biology Center, State Key Laboratory of Trauma, Burn, and Combined Injury, Research Institute of Surgery and Daping Hospital, Third Military Medical University, Chongqing, China.
Chen JF; Leiden Academic Centre for Drug Research, Leiden University, Leiden, The Netherlands.

Mol Psychiatry ; 20(11): 1339-49, 2015 Nov.

Article in En | MEDLINE | ID: mdl-25687775

Subject(s)

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Signal Transduction / Cyclic AMP Response Element-Binding Protein / Receptors, Adenosine A2 / Hippocampus / Memory Disorders Limits: Animals / Humans Language: En Journal: Mol Psychiatry Journal subject: BIOLOGIA MOLECULAR / PSIQUIATRIA Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google