Epigenetic mechanisms of induced pluripotency.
Contemp Oncol (Pozn)
; 19(1A): A30-8, 2015.
Article
in En
| MEDLINE
| ID: mdl-25691819
ABSTRACT
Reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) requires profound alterations in the epigenetic landscape. During reprogramming, a change in chromatin structure resets the gene expression and stabilises self-renewal. Reprogramming is a highly inefficient process, in part due to multiple epigenetic barriers. Although many epigenetic factors have already been shown to affect self-renewal and pluripotency in embryonic stem cells (ESCs), only a few of them have been examined in the context of dedifferentiation. In order to improve current protocols of iPSCs generation, it is essential to identify epigenetic drivers and blockages of somatic cell reprogramming.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Prognostic_studies
Language:
En
Journal:
Contemp Oncol (Pozn)
Year:
2015
Document type:
Article
Affiliation country:
Polonia