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A Photorhabdus natural product inhibits insect juvenile hormone epoxide hydrolase.
Nollmann, Friederike I; Heinrich, Antje K; Brachmann, Alexander O; Morisseau, Christophe; Mukherjee, Krishnendu; Casanova-Torres, Ángel M; Strobl, Frederic; Kleinhans, David; Kinski, Sebastian; Schultz, Katharina; Beeton, Michael L; Kaiser, Marcel; Chu, Ya-Yun; Phan Ke, Long; Thanwisai, Aunchalee; Bozhüyük, Kenan A J; Chantratita, Narisara; Götz, Friedrich; Waterfield, Nick R; Vilcinskas, Andreas; Stelzer, Ernst H K; Goodrich-Blair, Heidi; Hammock, Bruce D; Bode, Helge B.
Affiliation
  • Nollmann FI; Merck Stiftungsprofessur für Molekulare Biotechnologie, Fachbereich Biowissenschaften, Goethe Universität Frankfurt, 60438 Frankfurt am Main (Germany).
Chembiochem ; 16(5): 766-71, 2015 Mar 23.
Article in En | MEDLINE | ID: mdl-25711603
ABSTRACT
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urea / Biological Products / Photorhabdus / Enzyme Inhibitors / Epoxide Hydrolases Limits: Animals Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urea / Biological Products / Photorhabdus / Enzyme Inhibitors / Epoxide Hydrolases Limits: Animals Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2015 Document type: Article