Haemophilus parasuis induces activation of NF-κB and MAP kinase signaling pathways mediated by toll-like receptors.
Mol Immunol
; 65(2): 360-6, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-25733389
ABSTRACT
Glässer's disease in pigs caused by Haemophilus parasuis is characterized by a severe membrane inflammation. In our previous study, we have identified activation of the transcription factor NF-κB after H. parasuis infection of porcine epithelial cells. In this study, we found that H. parasuis infection also contributed to the activation of p38/JNK MAPK pathway predominantly linked to inflammation, but not the ERK MAPK pathway associated with growth, differentiation and development. Inhibition of NF-κB, p38 and JNK but not ERK activity significantly reduced IL-8 and CCL4 expression by H. parasuis. We also found TLR1, TLR2, TLR4 and TLR6 were required for NF-κB, p38 and JNK MAPK activation. Furthermore, MyD88 and TRIF signaling cascades were essential for H. parasuis-induced NF-κB activation. These results provided new insights into the molecular pathways underlying the inflammatory response induced by H. parasuis.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine Diseases
/
NF-kappa B
/
MAP Kinase Signaling System
/
Haemophilus parasuis
/
Toll-Like Receptors
/
Haemophilus Infections
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Mol Immunol
Year:
2015
Document type:
Article
Affiliation country:
China