Synthesis of chiral triazine coupling reagents based on esters of N-alkylproline and their application in the enantioselective incorporation of D or L amino acid residue directly from racemic substrate.
Acta Pol Pharm
; 71(6): 994-1003, 2014.
Article
in En
| MEDLINE
| ID: mdl-25745772
ABSTRACT
Esters of N-methylproline and N-allylproline were prepared and used as component for synthesis of chiral triazine based coupling reagents. N-Triazinylammonium tetrafluoroborate obtained from methylester of L-N-methylproline, 2-chloro-4,6-dimethozxy-1,3,5-triazine and tetrafluoroboric acid in the coupling of rac-Z- A1a-OH with glycine methylester preferred formation of D-Z-AlaGly-OMe with L/D ratio 21/79. Coupling reagent prepared from D enantiomer of N-methylproline gave L-Z-AlaGly-OMe with L/D ratio 75/25.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides
/
Triazines
/
Boric Acids
/
Proline
Language:
En
Journal:
Acta Pol Pharm
Year:
2014
Document type:
Article