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The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.
Zhu, Yi; Tchkonia, Tamara; Pirtskhalava, Tamar; Gower, Adam C; Ding, Husheng; Giorgadze, Nino; Palmer, Allyson K; Ikeno, Yuji; Hubbard, Gene B; Lenburg, Marc; O'Hara, Steven P; LaRusso, Nicholas F; Miller, Jordan D; Roos, Carolyn M; Verzosa, Grace C; LeBrasseur, Nathan K; Wren, Jonathan D; Farr, Joshua N; Khosla, Sundeep; Stout, Michael B; McGowan, Sara J; Fuhrmann-Stroissnigg, Heike; Gurkar, Aditi U; Zhao, Jing; Colangelo, Debora; Dorronsoro, Akaitz; Ling, Yuan Yuan; Barghouthy, Amira S; Navarro, Diana C; Sano, Tokio; Robbins, Paul D; Niedernhofer, Laura J; Kirkland, James L.
Affiliation
  • Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Gower AC; Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
  • Ding H; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Ikeno Y; Departments of Pathology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.
  • Hubbard GB; Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA.
  • Lenburg M; Departments of Pathology, Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center, San Antonio, TX, USA.
  • O'Hara SP; Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA.
  • LaRusso NF; Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.
  • Miller JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Roos CM; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Verzosa GC; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Wren JD; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Farr JN; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Khosla S; Department of Biochemistry and Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
  • Stout MB; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • McGowan SJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Fuhrmann-Stroissnigg H; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Gurkar AU; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Zhao J; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Colangelo D; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Dorronsoro A; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Ling YY; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Barghouthy AS; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Navarro DC; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Sano T; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Robbins PD; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Niedernhofer LJ; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
  • Kirkland JL; Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA.
Aging Cell ; 14(4): 644-58, 2015 Aug.
Article in En | MEDLINE | ID: mdl-25754370
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Quercetin / Aging / Cellular Senescence / Transcriptome / Dasatinib Type of study: Prognostic_studies Aspects: Patient_preference Language: En Journal: Aging Cell Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osteoporosis / Quercetin / Aging / Cellular Senescence / Transcriptome / Dasatinib Type of study: Prognostic_studies Aspects: Patient_preference Language: En Journal: Aging Cell Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido