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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
Wityak, John; McGee, Kevin F; Conlon, Michael P; Song, Ren Hua; Duffy, Bryan C; Clayton, Brent; Lynch, Michael; Wang, Gwen; Freeman, Emily; Haber, James; Kitchen, Douglas B; Manning, David D; Ismail, Jiffry; Khmelnitsky, Yuri; Michels, Peter; Webster, Jeff; Irigoyen, Macarena; Luche, Michele; Hultman, Monica; Bai, Mei; Kuok, IokTeng D; Newell, Ryan; Lamers, Marieke; Leonard, Philip; Yates, Dawn; Matthews, Kim; Ongeri, Lynette; Clifton, Steve; Mead, Tania; Deupree, Susan; Wheelan, Pat; Lyons, Kathy; Wilson, Claire; Kiselyov, Alex; Toledo-Sherman, Leticia; Beconi, Maria; Muñoz-Sanjuan, Ignacio; Bard, Jonathan; Dominguez, Celia.
Affiliation
  • Wityak J; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • McGee KF; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Conlon MP; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Song RH; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Duffy BC; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Clayton B; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Lynch M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Wang G; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Freeman E; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Haber J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Kitchen DB; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Manning DD; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Ismail J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Khmelnitsky Y; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Michels P; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Webster J; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Irigoyen M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Luche M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Hultman M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Bai M; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Kuok ID; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Newell R; ‡Albany Molecular Research Inc. (AMRI), 26 Corporate Circle, Albany, New York 12212-5098, United States.
  • Lamers M; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Leonard P; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Yates D; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Matthews K; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Ongeri L; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Clifton S; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Mead T; §BioFocus Discovery Services, Charles River Laboratories, Chesterford Research Park, Little Chesterford, CB10 1XL, United Kingdom.
  • Deupree S; ∥Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States.
  • Wheelan P; ∥Tandem Laboratories, 2202 Ellis Road, Durham, North Carolina 27703, United States.
  • Lyons K; ⊥Pharmacokinetics Consultant to CHDI, P.O. Box 64, Holland, New York 14080, United States.
  • Wilson C; #Evotec, 114 Milton Park, Abingdon, OX14 4SA, United Kingdom.
  • Kiselyov A; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • Toledo-Sherman L; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • Beconi M; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • Muñoz-Sanjuan I; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • Bard J; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
  • Dominguez C; †CHDI Foundation, Inc., 6080 Center Drive, Suite 100, Los Angeles, California 90045, United States.
J Med Chem ; 58(7): 2967-87, 2015 Apr 09.
Article in En | MEDLINE | ID: mdl-25760409
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitogen-Activated Protein Kinase 10 / Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mitogen-Activated Protein Kinase 10 / Protein Kinase Inhibitors Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2015 Document type: Article Affiliation country: Estados Unidos