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A new water soluble MAPK activator exerts antitumor activity in melanoma cells resistant to the BRAF inhibitor vemurafenib.
Graziani, Grazia; Artuso, Simona; De Luca, Anastasia; Muzi, Alessia; Rotili, Dante; Scimeca, Manuel; Atzori, Maria Grazia; Ceci, Claudia; Mai, Antonello; Leonetti, Carlo; Levati, Lauretta; Bonanno, Elena; Tentori, Lucio; Caccuri, Anna Maria.
Affiliation
  • Graziani G; Department of Systems Medicine, University of "Tor Vergata", Rome, Italy.
  • Artuso S; Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy.
  • De Luca A; The NAST Centre for Nanoscience & Nanotechnology & Innovative Instrumentation, University of "Tor Vergata", Rome, Italy.
  • Muzi A; Department of Systems Medicine, University of "Tor Vergata", Rome, Italy.
  • Rotili D; Department of Drug Chemistry and Technologies, "Sapienza" University, Rome, Italy.
  • Scimeca M; Department of Biomedicine and Prevention, University of "Tor Vergata", Rome, Italy; TMALab s.r.l., Spin-off of University of "Tor Vergata", Rome, Italy.
  • Atzori MG; Department of Systems Medicine, University of "Tor Vergata", Rome, Italy.
  • Ceci C; Department of Systems Medicine, University of "Tor Vergata", Rome, Italy.
  • Mai A; Department of Drug Chemistry and Technologies, "Sapienza" University, Rome, Italy; Pasteur Institute, Cenci-Bolognetti Foundation, "Sapienza" University, Rome, Italy.
  • Leonetti C; Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute, Rome, Italy.
  • Levati L; Laboratory of Molecular Oncology, "Istituto Dermopatico dell'Immacolata" - IRCCS, Rome, Italy.
  • Bonanno E; Department of Biomedicine and Prevention, University of "Tor Vergata", Rome, Italy; TMALab s.r.l., Spin-off of University of "Tor Vergata", Rome, Italy.
  • Tentori L; Department of Systems Medicine, University of "Tor Vergata", Rome, Italy.
  • Caccuri AM; The NAST Centre for Nanoscience & Nanotechnology & Innovative Instrumentation, University of "Tor Vergata", Rome, Italy; Department of Experimental Medicine and Surgery, University of "Tor Vergata", Rome, Italy. Electronic address: caccuri@uniroma2.it.
Biochem Pharmacol ; 95(1): 16-27, 2015 May 01.
Article in En | MEDLINE | ID: mdl-25795251
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Drug Resistance, Neoplasm / MAP Kinase Signaling System / Proto-Oncogene Proteins B-raf / Indoles / Melanoma / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2015 Document type: Article Affiliation country: Italia Country of publication: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Drug Resistance, Neoplasm / MAP Kinase Signaling System / Proto-Oncogene Proteins B-raf / Indoles / Melanoma / Antineoplastic Agents Limits: Animals / Humans / Male Language: En Journal: Biochem Pharmacol Year: 2015 Document type: Article Affiliation country: Italia Country of publication: Reino Unido