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The gene for an exported antigen of the malaria parasite Plasmodium falciparum cloned and expressed in Escherichia coli.
Nucleic Acids Res ; 13(2): 369-79, 1985 Jan 25.
Article in En | MEDLINE | ID: mdl-2582354
An exported protein of the erythrocytic stages of the malaria parasite, Plasmodium falciparum, has epitope(s) in common with the surface of the sporozoite stage (1). Two cDNA clones encoding this protein, Ag5.1, have now been isolated and expressed in Escherichia coli. The coding sequence contains a region with strong homology to that of the circumsporozoite protein of P. falciparum. Other features of the sequence can be explained in terms of the observed behaviour of the protein in the parasite life cycle. The Ag5.1 can now be synthesised in bacteria in sufficient amounts to analyse the immune response to this protein.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Antigens, Protozoan Language: En Journal: Nucleic Acids Res Year: 1985 Document type: Article Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Antigens, Protozoan Language: En Journal: Nucleic Acids Res Year: 1985 Document type: Article Country of publication: Reino Unido