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The NEDD8 inhibitor MLN4924 increases the size of the nucleolus and activates p53 through the ribosomal-Mdm2 pathway.
Bailly, A; Perrin, A; Bou Malhab, L J; Pion, E; Larance, M; Nagala, M; Smith, P; O'Donohue, M-F; Gleizes, P-E; Zomerdijk, J; Lamond, A I; Xirodimas, D P.
Affiliation
  • Bailly A; Centre de Recherche de Biochimie Macromoléculaire-UMR 5237, CNRS, Montpellier, France.
  • Perrin A; Centre de Recherche de Biochimie Macromoléculaire-UMR 5237, CNRS, Montpellier, France.
  • Bou Malhab LJ; Centre de Recherche de Biochimie Macromoléculaire-UMR 5237, CNRS, Montpellier, France.
  • Pion E; Centre de Recherche de Biochimie Macromoléculaire-UMR 5237, CNRS, Montpellier, France.
  • Larance M; Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland/UK.
  • Nagala M; Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland/UK.
  • Smith P; Millennium Pharmaceuticals Inc., Cambridge, MA, USA.
  • O'Donohue MF; Laboratoire de Biologie Moléculaire Eucaryote, UMR CNRS 5099, Bâtiment IBCG, Toulouse, France.
  • Gleizes PE; Laboratoire de Biologie Moléculaire Eucaryote, UMR CNRS 5099, Bâtiment IBCG, Toulouse, France.
  • Zomerdijk J; Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland/UK.
  • Lamond AI; Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland/UK.
  • Xirodimas DP; Centre de Recherche de Biochimie Macromoléculaire-UMR 5237, CNRS, Montpellier, France.
Oncogene ; 35(4): 415-26, 2016 Jan 28.
Article in En | MEDLINE | ID: mdl-25867069
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Ubiquitins / Cell Nucleolus / Genes, p53 / Caenorhabditis elegans / Cyclopentanes / Proto-Oncogene Proteins c-mdm2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2016 Document type: Article Affiliation country: Francia Country of publication: Reino Unido
Fulltext
Add to My VHL
Print
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Ubiquitins / Cell Nucleolus / Genes, p53 / Caenorhabditis elegans / Cyclopentanes / Proto-Oncogene Proteins c-mdm2 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Oncogene Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2016 Document type: Article Affiliation country: Francia Country of publication: Reino Unido