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A human monoclonal IgG that binds aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.
Levites, Yona; O'Nuallain, Brian; Puligedda, Rama Devudu; Ondrejcak, Tomas; Adekar, Sharad P; Chen, Cindy; Cruz, Pedro E; Rosario, Awilda M; Macy, Sallie; Mably, Alexandra J; Walsh, Dominic M; Vidal, Ruben; Solomon, Alan; Brown, Daniel; Rowan, Michael J; Golde, Todd E; Dessain, Scott K.
Affiliation
  • Levites Y; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610, dessains@mlhs.org levites.yona@ufl.edu.
  • O'Nuallain B; The Laboratory of Neurodegenerative Research, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115.
  • Puligedda RD; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096.
  • Ondrejcak T; Trinity College Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland.
  • Adekar SP; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096.
  • Chen C; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096.
  • Cruz PE; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.
  • Rosario AM; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.
  • Macy S; University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920.
  • Mably AJ; The Laboratory of Neurodegenerative Research, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115.
  • Walsh DM; The Laboratory of Neurodegenerative Research, Brigham and Women's Hospital, Harvard Institutes of Medicine, Boston, Massachusetts 02115.
  • Vidal R; Department of Pathology and Laboratory Medicine and the Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, and.
  • Solomon A; University of Tennessee Graduate School of Medicine, Knoxville, Tennessee 37920.
  • Brown D; Department of Pathology and Laboratory Medicine, Lehigh Valley Health Network, Allentown, Pennsylvania 18103.
  • Rowan MJ; Trinity College Institute of Neuroscience and Department of Pharmacology and Therapeutics, Trinity College, Dublin 2, Ireland.
  • Golde TE; Department of Neuroscience, Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, Gainesville, Florida 32610.
  • Dessain SK; Lankenau Institute for Medical Research, Wynnewood, Pennsylvania 19096, dessains@mlhs.org levites.yona@ufl.edu.
J Neurosci ; 35(16): 6265-76, 2015 Apr 22.
Article in En | MEDLINE | ID: mdl-25904780
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Amyloid beta-Peptides / Amyloid / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Neurosci Year: 2015 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Immunoglobulin G / Amyloid beta-Peptides / Amyloid / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Neurosci Year: 2015 Document type: Article Country of publication: Estados Unidos