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Succinylated Apoptolidins from Amycolatopsis sp. ICBB 8242.
Sheng, Yan; Fotso, Serge; Serrill, Jeffrey D; Shahab, Salmah; Santosa, Dwi Andreas; Ishmael, Jane E; Proteau, Philip J; Zabriskie, T Mark; Mahmud, Taifo.
Affiliation
  • Sheng Y; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
  • Fotso S; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
  • Serrill JD; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
  • Shahab S; ‡Indonesian Center for Biodiversity and Biotechnology, ICBB-Complex, Jl. Cilubang Nagrak No. 62, Situgede, Bogor 16115, Indonesia.
  • Santosa DA; ‡Indonesian Center for Biodiversity and Biotechnology, ICBB-Complex, Jl. Cilubang Nagrak No. 62, Situgede, Bogor 16115, Indonesia.
  • Ishmael JE; §Department of Soil Science and Land Resources, Faculty of Agriculture, Bogor Agricultural University, Bogor, Indonesia.
  • Proteau PJ; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
  • Zabriskie TM; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
  • Mahmud T; †Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, Oregon 97331-3507, United States.
Org Lett ; 17(10): 2526-9, 2015 May 15.
Article in En | MEDLINE | ID: mdl-25945812
ABSTRACT
Two new apoptolidins, 2'-O-succinyl-apoptolidin A (11) and 3'-O-succinyl-apoptolidin A (12), were isolated from the culture broth of an Indonesian Amycolatopsis sp. ICBB 8242. These compounds inhibit the proliferation and viability of human H292 and HeLa cells. However, in contrast to apoptolidin A (1), they do not inhibit cellular respiration in H292 cells. It is proposed that apoptolidins are produced and secreted in their succinylated forms and 1 is the hydrolysis product of 11 and 12.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actinomycetales / Macrolides Limits: Humans Country/Region as subject: Asia Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Actinomycetales / Macrolides Limits: Humans Country/Region as subject: Asia Language: En Journal: Org Lett Journal subject: BIOQUIMICA Year: 2015 Document type: Article Affiliation country: Estados Unidos