The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Autophagy
; 11(7): 1114-29, 2015.
Article
in En
| MEDLINE
| ID: mdl-26029847
Key words
ACTB actin, ß; CAMKK2, calcium/calmodulin-dependent protein kinase kinase 2, ß; CASP8, caspase 8; CFLAR CASP8 and FADD-like apoptosis regulator; CMML; CMML chronic myelomonocytic leukemia; CSF1; CSF1 colony stimulating factor 1 (macrophage); CSF1R colony stimulating factor 1 receptor; DEFA1 defensin α 1; DEFA3 defensin α 3 neutrophil-specific; DRS; dorsomorphin; EMR1 EGF-like module-containing mucin-like hormone receptor-like 1; FADD Fas (TNFRSF6)-associated via death domain; G-protein coupled 6; ITGAM integrin α M; MAP1LC3B/LC3B microtubule-associated protein 1 light chain 3 ß; P2RY6; P2RY6 pyrimidinergic receptor P2Y; PLC phospholipase; PLCB3 phospholipase C; PLCG2 phospholipase C gamma 2 (phosphatidylinositol-specific); PRKAA protein kinase AMP-activated; PRKAA1 protein kinase AMP-activated α 1 catalytic subunit; PRKAA1/AMPKα1; PRKAA2 protein kinase AMP-activated α 2 catalytic subunit; PRKAG1 protein kinase AMP-activated gamma 1 noncatalytic subunit; RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1; STK11 serine/threonine kinase 11; TFRC transferrin receptor; UDP uridine diphosphate; ULK1 unc-51 like autophagy activating kinase 1; WT wild-type; apoptosis-related cysteine peptidase; autophagy; differentiation; primary monocyte; ß 3 (phosphatidylinositol-specific)
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autophagy
/
Monocytes
/
Signal Transduction
/
Leukemia, Myeloid
/
Cell Differentiation
/
Macrophage Colony-Stimulating Factor
/
AMP-Activated Protein Kinases
Type of study:
Prognostic_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Autophagy
Year:
2015
Document type:
Article
Affiliation country:
Francia