Irreversible electroporation for nonthermal tumor ablation in patients with hepatocellular carcinoma: initial clinical experience in Japan.
Jpn J Radiol
; 33(7): 424-32, 2015 Jul.
Article
in En
| MEDLINE
| ID: mdl-26032929
ABSTRACT
PURPOSE:
This clinical study was conducted to evaluate the safety and short-term outcomes of irreversible electroporation (IRE) for the treatment of patients with hepatocellular carcinoma (HCC) in Japan. MATERIALS ANDMETHODS:
The study was designed in a prospective setting. Five patients (3 men and 2 women; mean age, 66.6 ± 5.8 years) with 6 HCCs were enrolled and treated using percutaneous ultrasound (US)-guided IRE. Safety was assessed based on adverse events and laboratory values. Local control was assessed using contrast-enhanced US with a perflubutane microbubble contrast agent, contrast-enhanced multiphase CT, and gadoxetic acid-enhanced MRI (EOB-MRI) at designated points.RESULTS:
The tumors ranged in diameter from 11 to 28 mm (mean diameter, 17.5 ± 6.3 mm). Five of the 6 tumors (83 %) were successfully treated, with no local recurrence to date (mean follow-up 244 ± 55 days). In 1 lesion located in liver segment 1, residual tumor was diagnosed at 7 days after intervention by follow-up EOB-MRI. No serious complications related to the IRE procedure were observed.CONCLUSION:
The results of this study suggest that image-guided percutaneous IRE can achieve satisfactory local disease control, particularly for small HCCs, and is well tolerated by patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Electroporation
/
Carcinoma, Hepatocellular
/
Ablation Techniques
/
Liver Neoplasms
Type of study:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Jpn J Radiol
Journal subject:
DIAGNOSTICO POR IMAGEM
/
RADIOLOGIA
/
RADIOTERAPIA
Year:
2015
Document type:
Article