Negative Feedback of Glycolysis and Oxidative Phosphorylation: Mechanisms of and Reasons for It.
Biochemistry (Mosc)
; 80(5): 559-64, 2015 May.
Article
in En
| MEDLINE
| ID: mdl-26071773
ABSTRACT
There are two main pathways of ATP biosynthesis:
glycolysis and oxidative phosphorylation. As a rule, the two pathways are not fully active in a single cell. In this review, we discuss mechanisms of glycolytic inhibition of respiration (Warburg and Crabtree effects). What are the reasons for the existence of this negative feedback? It is known that maximal activation of both processes can cause generation of reactive oxygen species. Oxidative phosphorylation is more efficient from the energy point of view, while glycolysis is safer and favors biomass synthesis. This might be the reason why quiescent cells are mainly using oxidative phosphorylation, while the quickly proliferating ones - glycolysis.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxidative Phosphorylation
/
Oxygen Consumption
/
Saccharomyces cerevisiae
/
Adenosine Triphosphate
/
Glycolysis
Language:
En
Journal:
Biochemistry (Mosc)
Year:
2015
Document type:
Article
Affiliation country:
Rusia