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First detection of Aspergillus fumigatus azole-resistant strain due to Cyp51A TR46/Y121F/T289A in an azole-naive patient in Spain.
Pelaez, T; Monteiro, M C; Garcia-Rubio, R; Bouza, E; Gomez-Lopez, A; Mellado, E.
Affiliation
  • Pelaez T; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
  • Monteiro MC; Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
  • Garcia-Rubio R; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
  • Bouza E; Clinical Microbiology and Infectious Diseases Department, Hospital General Universitario Gregorio Marañón and Department of Medicine, Faculty of Medicine, Universidad Complutense, Madrid, Spain.
  • Gomez-Lopez A; Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
  • Mellado E; Mycology Reference Laboratory, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
New Microbes New Infect ; 6: 33-4, 2015 Jul.
Article in En | MEDLINE | ID: mdl-26082842
ABSTRACT
We report the first isolation of a voriconazole-resistant Aspergillus fumigatus strain harbouring the azole resistance mechanism TR46/Y121F/T289A, recovered from an azole-naive patient in Spain with chronic obstructive pulmonary disease. This new finding in Spain suggests the spread of this resistance mechanism and reinforces the need for antifungal susceptibility surveillance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: New Microbes New Infect Year: 2015 Document type: Article Affiliation country: España
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies Language: En Journal: New Microbes New Infect Year: 2015 Document type: Article Affiliation country: España