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Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
Mor, Visesato; Rella, Antonella; Farnoud, Amir M; Singh, Ashutosh; Munshi, Mansa; Bryan, Arielle; Naseem, Shamoon; Konopka, James B; Ojima, Iwao; Bullesbach, Erika; Ashbaugh, Alan; Linke, Michael J; Cushion, Melanie; Collins, Margaret; Ananthula, Hari Krishna; Sallans, Larry; Desai, Pankaj B; Wiederhold, Nathan P; Fothergill, Annette W; Kirkpatrick, William R; Patterson, Thomas; Wong, Lai Hong; Sinha, Sunita; Giaever, Guri; Nislow, Corey; Flaherty, Patrick; Pan, Xuewen; Cesar, Gabriele Vargas; de Melo Tavares, Patricia; Frases, Susana; Miranda, Kildare; Rodrigues, Marcio L; Luberto, Chiara; Nimrichter, Leonardo; Del Poeta, Maurizio.
Affiliation
  • Mor V; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Rella A; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Farnoud AM; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Singh A; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Munshi M; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Bryan A; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Naseem S; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Konopka JB; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.
  • Ojima I; Department of Chemistry and Institute of Chemical Biology and Drug Discovery, Stony Brook University, Stony Brook, New York, USA.
  • Bullesbach E; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA.
  • Ashbaugh A; Department of Veterans Affairs Medical Center, Cincinnati, Ohio, USA.
  • Collins M; University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
  • Ananthula HK; Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
  • Sallans L; Department of Chemistry, University of Cincinnati, Cincinnati, Ohio, USA.
  • Desai PB; Department of Pharmaceutical Sciences, University of Cincinnati, Cincinnati, Ohio, USA.
  • Wiederhold NP; Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Fothergill AW; Department of Pathology, Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Kirkpatrick WR; Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Patterson T; Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA.
  • Wong LH; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada.
  • Sinha S; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada.
  • Giaever G; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada.
  • Nislow C; Department of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Colombia, Canada.
  • Flaherty P; Department of Biomedical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts, USA.
  • Pan X; Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas, USA.
  • Cesar GV; Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Melo Tavares P; Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Frases S; Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Luberto C; Department of Physiology and Biophysics, Stony Brook University, Stony Brook, New York, USA.
  • Nimrichter L; Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Del Poeta M; Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA maurizio.delpoeta@stonybrook.edu.
mBio ; 6(3): e00647, 2015 Jun 23.
Article in En | MEDLINE | ID: mdl-26106079
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingolipids / Benzyl Compounds / Biosynthetic Pathways / Fungi / Antifungal Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: MBio Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sphingolipids / Benzyl Compounds / Biosynthetic Pathways / Fungi / Antifungal Agents Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: MBio Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos