Second allogeneic hematopoietic stem cell transplantation in children with severe aplastic anemia.
Bone Marrow Transplant
; 50(10): 1312-5, 2015 Oct.
Article
in En
| MEDLINE
| ID: mdl-26121106
ABSTRACT
The outcome of 55 children with severe aplastic anemia (SAA) who received a second hematopoietic stem cell transplantation (HSCT) was retrospectively analyzed using the registration data of the Japanese Society for Hematopoietic Cell Transplantation. The 5-year overall survival (OS) and failure-free survival (FFS) after the second transplantation were 82.9% (95% confidence interval (CI), 69.7-90.8)) and 81.2% (95% CI, 67.8-89.4), respectively. FFS was significantly better when the interval between the first and second transplantation was >60 days (88.9%; 95% CI, 73.0-95.7) than when it was ⩽60 days (61.4%; 95% CI, 33.3-80.5; P=0.026). All 12 patients who were conditioned with regimens containing fludarabine and melphalan were alive with hematopoietic recovery. These findings justify the recommendation of a second HSCT for children with SAA who have experienced graft failure after first HSCT.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transplantation, Homologous
/
Hematopoietic Stem Cell Transplantation
/
Transplantation Conditioning
/
Anemia, Aplastic
Limits:
Adolescent
/
Child
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Child, preschool
/
Female
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Humans
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Infant
/
Male
Language:
En
Journal:
Bone Marrow Transplant
Journal subject:
TRANSPLANTE
Year:
2015
Document type:
Article
Affiliation country:
Japón