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Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy.
Dorywalska, Magdalena; Strop, Pavel; Melton-Witt, Jody A; Hasa-Moreno, Adela; Farias, Santiago E; Galindo Casas, Meritxell; Delaria, Kathy; Lui, Victor; Poulsen, Kris; Sutton, Janette; Bolton, Gary; Zhou, Dahui; Moine, Ludivine; Dushin, Russell; Tran, Thomas-Toan; Liu, Shu-Hui; Rickert, Mathias; Foletti, Davide; Shelton, David L; Pons, Jaume; Rajpal, Arvind.
Affiliation
  • Dorywalska M; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Strop P; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Melton-Witt JA; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Hasa-Moreno A; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Farias SE; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Galindo Casas M; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Delaria K; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Lui V; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Poulsen K; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Sutton J; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Bolton G; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Zhou D; Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America.
  • Moine L; Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America.
  • Dushin R; Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America.
  • Tran TT; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Liu SH; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Rickert M; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Foletti D; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Shelton DL; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Pons J; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
  • Rajpal A; Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America.
PLoS One ; 10(7): e0132282, 2015.
Article in En | MEDLINE | ID: mdl-26161543
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Drug Carriers / Aminobenzoates Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Drug Carriers / Aminobenzoates Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2015 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos