The use of r-hFSH in treatment of idiopathic male factor infertility before ICSI.
Eur Rev Med Pharmacol Sci
; 19(12): 2162-7, 2015 Jun.
Article
in En
| MEDLINE
| ID: mdl-26166637
ABSTRACT
OBJECTIVE:
To evaluate the efficacy of pre-treatment of idiopathic oligozoospermic patients with r-hFSH to improve the clinical results of ICSI. PATIENTS ANDMETHODS:
82 infertile couples due to male factor who attended our center were included in the study. Thirty-six were randomized to the treatment group (group A) and forty-six to the control group (group B). The male partners in group A were treated with recombinant human FSH (r-hFSH; Gonal F®) 150 IU subcutaneously three times a week for a 3-months period. The control group (group B) did not receive any treatment. After the treatment couples of both groups underwent a cycle of ICSI.RESULTS:
The fertilization rate was comparable in both groups. However, in the treatment group (group A), the clinical pregnancy rate was significantly higher (42%) compared to the control group (group B) (20%) (p < 0.02). Also, the implantation rate was significantly higher in treatment group (26%) compared to the control (15%) (p < 0.04). Miscarriage rate was lower (15.7%) in the treatment group than in the control (43.7%), and this difference was statistically significant (p < 0.05).CONCLUSIONS:
Treatment of idiopathic male factor infertility with r-hFSH before ICSI improves clinical pregnancy rate, increases implantation rate and decreases the early pregnancy loss.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy Rate
/
Sperm Injections, Intracytoplasmic
/
Follicle Stimulating Hormone, Human
/
Infertility, Male
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
FARMACOLOGIA
/
TOXICOLOGIA
Year:
2015
Document type:
Article
Affiliation country:
Italia