Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis.
Phytochemistry
; 117: 424-435, 2015 Sep.
Article
in En
| MEDLINE
| ID: mdl-26188915
ABSTRACT
Twenty-four compounds, including the previously unknown artoxanthocarpuone A, artoxanthocarpuone B, hydroxylakoochin A, methoxylakoochin A, epoxylakoochin A, and artoxanthol, were isolated and characterized spectroscopically. Among them, artoxanthol is stilbene oligomer presumably constructed in a 5,11,12-triphenyl hexahydrochrysene scaffold by a Diels-Alder type of reaction, for which a biosynthetic pathway is proposed. Artoxanthol, alboctalol, steppogenin, norartocarpetin, resveratrol, oxyresveratrol, and chlorophorin potently inhibited mushroom tyrosinase activity with IC50 values from 0.9 to 5.7 µM that were all far stronger than the positive controls. Artoxanthocarpuone A, artoxanthocarpuone B, methoxylakoochin A, lakoochin A, cudraflavone C, artonin A, resveratrol, and chlorophorin reduced tyrosinase activity and inhibited α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells without affecting cell proliferation. Collectively, the results suggest that the constituents of Artocarpus xanthocarpus have potential to be used as depigmentation agents.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Artocarpus
/
Melanins
/
Antioxidants
Limits:
Animals
Language:
En
Journal:
Phytochemistry
Year:
2015
Document type:
Article
Affiliation country:
Taiwán