Investigation of the Capture of Magnetic Particles From High-Viscosity Fluids Using Permanent Magnets.

GOAL: This paper investigates the practicality of using a small, permanent magnet to capture magnetic particles out of high-viscosity biological fluids, such as synovial fluid. METHODS: Numerical simulations are used to predict the trajectory of magnetic particles toward the permanent magnet. The simulations are used to determine a "collection volume" with a time-dependent size and shape, which determines the number of particles that can be captured from the fluid in a given amount of time. RESULTS: The viscosity of the fluid strongly influences the velocity of the magnetic particles toward the magnet, hence, the collection volume after a given time. In regards to the design of the magnet, the overall size is shown to most strongly influence the collection volume in comparison to the magnet shape or aspect ratio. CONCLUSION: Numerical results showed good agreement with in vitro experimental magnetic collection results. SIGNIFICANCE: In the long term, this paper aims to facilitate optimization of the collection of magnetic particle-biomarker conjugates from high-viscosity biological fluids without the need to remove the fluid from a patient.