NOP14 suppresses breast cancer progression by inhibiting NRIP1/Wnt/ß-catenin pathway.
Oncotarget
; 6(28): 25701-14, 2015 Sep 22.
Article
in En
| MEDLINE
| ID: mdl-26213846
ABSTRACT
NOP14, which is functionally conserved among eukaryotes, has been implicated in cancer development. Here, we show that NOP14 is poorly expressed in breast cancer cells and invasive breast cancer tissues. In vivo and in vitro studies indicated that NOP14 suppressed the tumorigenesis and metastasis of breast cancer cells. Further investigations revealed that NOP14 enhanced ERα expression and inhibited the Wnt/ß-catenin pathway by up-regulating NRIP1 expression. Survival analysis indicated that low NOP14 expression was significantly associated with poor overall survival (P = 0.0006) and disease-free survival (P = 0.0007), suggesting that NOP14 is a potential prognostic factor in breast cancer. Taken together, our findings reveal that NOP14 may suppress breast cancer progression and provide new insights into the development of targeted therapeutic agents for breast cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Breast Neoplasms
/
Nuclear Proteins
/
Biomarkers, Tumor
/
Adaptor Proteins, Signal Transducing
/
Beta Catenin
/
Wnt Signaling Pathway
Type of study:
Prognostic_studies
Limits:
Adult
/
Animals
/
Female
/
Humans
Language:
En
Journal:
Oncotarget
Year:
2015
Document type:
Article
Affiliation country:
China
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA