[Analysis of Cytokines Related to Helper T and Regulatory T Cells in the Vitreous of Uveitis Patients].
Nippon Ganka Gakkai Zasshi
; 119(6): 395-401, 2015 Jun.
Article
in Ja
| MEDLINE
| ID: mdl-26214890
ABSTRACT
PURPOSE:
To investigate helper T (Th) cell-related cytokines elevated in the vitreous of endogenous uveitis (EU), and to compare these with those of acute retinal necrosis (ARN).METHODS:
Vitreous fluids were obtained from 23 eyes of EU patients, 4 eyes of ARN patients, and 14 eyes of patients with epiretinal membrane (ERM) who had had vitrectomy surgery. The vitreous levels of interleukin (IL)-1, IL-4, IL-6, IL-10, IL-17A, IL-17F, IL-21, IL-22, IL-23, IL-25, IL-31, IL-33, interferon (IFN)-γ, soluble CD40 ligand (sCD40L) and tumor necrosis factor (TNF)-α were measured.RESULTS:
The vitreous cytokine levels of IL-6, IL-10, IL-31, IFN-γ and TNF-α in the EU patients were significantly higher than in the ERM patients. On the other hand, the levels of IL-1ß, IL-6, IL-10, IL-31, IFN-γ, sCD40L and TNF-α were significantly higher in the ARN patients than in the EU patients, while those of IL-4, IL-17A and IL-22 were higher in the EU patients than in the ARN patients although they were not significant.CONCLUSIONS:
It is suggested that Th1-, Th2- and Th17 cells are related to the development of EU, and Th1- and regulatory T cells to that of ARN, and that the severity of ocular inflammation may be associated with the activity of Th1 cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uveitis
/
Vitreous Body
/
Cytokines
/
T-Lymphocytes, Regulatory
/
T-Lymphocytes, Helper-Inducer
Limits:
Female
/
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Nippon Ganka Gakkai Zasshi
Year:
2015
Document type:
Article