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Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.
Perin, Paula M; Haid, Sibylle; Brown, Richard J P; Doerrbecker, Juliane; Schulze, Kai; Zeilinger, Carsten; von Schaewen, Markus; Heller, Brigitte; Vercauteren, Koen; Luxenburger, Eva; Baktash, Yasmine M; Vondran, Florian W R; Speerstra, Sietkse; Awadh, Abdullah; Mukhtarov, Furkat; Schang, Luis M; Kirschning, Andreas; Müller, Rolf; Guzman, Carlos A; Kaderali, Lars; Randall, Glenn; Meuleman, Philip; Ploss, Alexander; Pietschmann, Thomas.
Affiliation
  • Perin PM; Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Haid S; Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Brown RJ; Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Doerrbecker J; Institute of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research; a joint venture between the Medical School Hannover and the Helmholtz Centre for Infection Research, Hannover, Germany.
  • Schulze K; Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Braunschweig, Germany.
  • Zeilinger C; Institute of Organic Chemistry and Center of Biomolecular Drug Research, Leibniz Universität, Hannover, Germany.
  • von Schaewen M; Department of Molecular Biology, Princeton University, Princeton, NJ.
  • Heller B; Department of Molecular Biology, Princeton University, Princeton, NJ.
  • Vercauteren K; Center for Vaccinology, Ghent University, Ghent, Belgium.
  • Luxenburger E; Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.
  • Baktash YM; Department of Microbiology, The University of Chicago, Chicago, IL.
  • Vondran FW; ReMediES, Department of General, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany.
  • Speerstra S; German Centre for Infection Research, Hannover-Braunschweig, Germany.
  • Awadh A; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
  • Mukhtarov F; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
  • Schang LM; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
  • Kirschning A; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
  • Müller R; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
  • Guzman CA; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
  • Kaderali L; Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.
  • Randall G; Li Ka Shing Institute of Virology, University of Alberta, Edmonton, AB, Canada.
  • Meuleman P; Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB, Canada.
  • Ploss A; Institute of Organic Chemistry and Center of Biomolecular Drug Research, Leibniz Universität, Hannover, Germany.
  • Pietschmann T; Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany.
Hepatology ; 63(1): 49-62, 2016 Jan.
Article in En | MEDLINE | ID: mdl-26248546
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flunarizine / Viral Fusion Proteins / Hepacivirus / Virus Internalization Limits: Humans Language: En Journal: Hepatology Year: 2016 Document type: Article Affiliation country: Alemania Country of publication: Estados Unidos
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flunarizine / Viral Fusion Proteins / Hepacivirus / Virus Internalization Limits: Humans Language: En Journal: Hepatology Year: 2016 Document type: Article Affiliation country: Alemania Country of publication: Estados Unidos