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Quantitative activation-induced manganese-enhanced MRI reveals severity of Parkinson's disease in mice.
Kikuta, Satomi; Nakamura, Yukiyo; Yamamura, Yukio; Tamura, Atsushi; Homma, Noriyasu; Yanagawa, Yuchio; Tamura, Hajime; Kasahara, Jiro; Osanai, Makoto.
Affiliation
  • Kikuta S; 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [3] Research Fellow of the Japan Society for the Promotion of Science.
  • Nakamura Y; Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
  • Yamamura Y; Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
  • Tamura A; 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan.
  • Homma N; Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
  • Yanagawa Y; 1] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan [2] Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Japan.
  • Tamura H; Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
  • Kasahara J; Graduate School and Faculty of Pharmaceutical Sciences, Institute of Biomedical Sciences, Tokushima University, 1-78 Shoumachi, Tokushima 770-8505, Japan.
  • Osanai M; 1] Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan [2] CREST, Japan Science and Technology Agency, 4-1-8 Honcho, Kawaguchi 332-0012, Japan.
Sci Rep ; 5: 12800, 2015 Aug 10.
Article in En | MEDLINE | ID: mdl-26255701
ABSTRACT
We demonstrate that activation-induced manganese-enhanced magnetic resonance imaging with quantitative determination of the longitudinal relaxation time (qAIM-MRI) reveals the severity of Parkinson's disease (PD) in mice. We first show that manganese ion-accumulation depends on neuronal activity. A highly active region was then observed by qAIM-MRI in the caudate-putamen in PD-model mice that was significantly correlated to the severity of PD, suggesting its involvement in the expression of PD symptoms.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Imaging / Contrast Media / MPTP Poisoning / Manganese Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2015 Document type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Magnetic Resonance Imaging / Contrast Media / MPTP Poisoning / Manganese Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals Language: En Journal: Sci Rep Year: 2015 Document type: Article