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Lupane- and Friedelane-Type Triterpenoids from Celastrus stylosus.
Ying, You-Min; Li, Cui-Yu; Chen, Yan; Xiang, Jia-Gui; Fang, Ling; Yao, Jian-Biao; Wang, Fa-Song; Wang, Ru-Wei; Shan, Wei-Guang; Zhan, Zha-Jun.
Affiliation
  • Ying YM; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
  • Li CY; Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
  • Chen Y; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
  • Xiang JG; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
  • Fang L; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)).
  • Yao JB; Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
  • Wang FS; Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
  • Wang RW; Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province and College of Chemistry and Environmental Engineering, Hubei University for Nationalities, Enshi 445000, P. R. China.
  • Shan WG; Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd., Hangzhou 310052, P. R. China.
  • Zhan ZJ; College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China, (phone/fax: +86-571-88871075 (Z.-J. Zhan), +86-571-88320554 (W.-G. Shan); , (Z.-J. Zhan), (W.-G. Shan)). tianranyaowu@zjut.edu.cn.
Chem Biodivers ; 12(8): 1222-8, 2015 Aug.
Article in En | MEDLINE | ID: mdl-26265574
ABSTRACT
Two new triterpenoids, 30-hydroxylup-20(29)-ene 3ß-caffeate (1) and 24-nor-friedelan-6α,10-dihydroxy-1,2-dioxo-4,7-dien-29-oic acid (2), together with eight known compounds 3-10, were isolated from the roots of Celastrus stylosus. The structures of these compounds were elucidated on the basis of spectroscopic analyses. To the best of our knowledge, this represents the first study on the chemical constituents of C. stylosus. The antiproliferative activities of the triterpenoids against six human cancer cell lines (PANC-1, A549, PC-3, HepG2, SGC-7901, and HCCLM3) were evaluated. Compounds 3, 4, and 10 exhibited comparable activities against PC-3 and HCCLM3 cell lines as the positive control taxol.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Celastrus / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triterpenes / Celastrus / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: Chem Biodivers Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article