Anti-proliferative activity of Monensin and its tertiary amide derivatives.

Huczynski, Adam; Klejborowska, Greta; Antoszczak, Michal; Maj, Ewa; Wietrzyk, Joanna

Huczynski, Adam; Klejborowska, Greta; Antoszczak, Michal; Maj, Ewa; Wietrzyk, Joanna.

Affiliation

Huczynski A; Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznan, Poland. Electronic address: adhucz@amu.edu.pl.
Klejborowska G; Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznan, Poland.
Antoszczak M; Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89 b, 61-614 Poznan, Poland.
Maj E; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.
Wietrzyk J; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114 Wroclaw, Poland.

Bioorg Med Chem Lett ; 25(20): 4539-43, 2015 Oct 15.

Article in En | MEDLINE | ID: mdl-26338363

ABSTRACT

ABSTRACT

New tertiary amide derivatives of polyether ionophore Monensin A (MON) were synthesised and their anti-proliferative activity against cancer cell lines was studied. Very high activity (IC50=0.09 µM) and selectivity (SI=232) of MON against human biphenotypic myelomonocytic leukemia cell line (MV4-11) was demonstrated. The MON derivatives obtained exhibit interesting anti-proliferative activity, high selectivity index and also are able to break the drug-resistance of cancer cell line.

Subject(s)
Key words

Anti-proliferative activity; Natural products; Polyether ionophores; Selectivity; Tertiary amides

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Monensin / Amides / Antineoplastic Agents Limits: Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2015 Document type: Article

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