Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity.
Diabetologia
; 59(1): 197-207, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26376797
ABSTRACT
AIMS/HYPOTHESIS:
The worldwide incidence of obesity and diabetes continues to rise at an alarming rate. A major cause of the morbidity and mortality associated with obesity and diabetes is heart disease, yet the mechanisms that lead to cardiovascular complications remain unclear.METHODS:
We performed cardiac MRI to assess left ventricular morphology and function during the development of moderate obesity and insulin resistance in a well-established canine model (n = 26). To assess the influence of dietary fat composition, we randomised animals to a traditional lard diet (rich in saturated and monounsaturated fat; n = 12), a salmon oil diet (rich in polyunsaturated fat; n = 8) or a control diet (n = 6).RESULTS:
High-fat feeding with lard increased body weight and fasting insulin and markedly reduced insulin sensitivity. Lard feeding also significantly reduced left ventricular function, evidenced by a worsening of circumferential strain and impairment in left ventricular torsion. High-fat feeding with salmon oil increased body weight; however, salmon oil feeding did not impair insulin sensitivity or cardiac function. CONCLUSIONS/INTERPRETATION:
These data emphasise the importance of dietary fat composition on both metabolic and cardiac function, and have important implications for the relationship between diet and health.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Insulin Resistance
/
Heart Diseases
/
Obesity
Type of study:
Incidence_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Diabetologia
Year:
2016
Document type:
Article
Affiliation country:
Estados Unidos