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Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity.
Simões, Bruno M; O'Brien, Ciara S; Eyre, Rachel; Silva, Andreia; Yu, Ling; Sarmiento-Castro, Aida; Alférez, Denis G; Spence, Kath; Santiago-Gómez, Angélica; Chemi, Francesca; Acar, Ahmet; Gandhi, Ashu; Howell, Anthony; Brennan, Keith; Rydén, Lisa; Catalano, Stefania; Andó, Sebastiano; Gee, Julia; Ucar, Ahmet; Sims, Andrew H; Marangoni, Elisabetta; Farnie, Gillian; Landberg, Göran; Howell, Sacha J; Clarke, Robert B.
Affiliation
  • Simões BM; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • O'Brien CS; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Eyre R; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Silva A; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Yu L; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Sarmiento-Castro A; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Alférez DG; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Spence K; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Santiago-Gómez A; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Chemi F; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.
  • Acar A; Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
  • Gandhi A; Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Southmoor Road, Manchester M23 9LT, UK.
  • Howell A; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Brennan K; Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
  • Rydén L; Department of Surgery, Clinical Sciences, Lund University, Skåne University Hospital, 21428 Malmö, Sweden.
  • Catalano S; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.
  • Andó S; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Cosenza, Italy.
  • Gee J; Cardiff School of Pharmacy and Pharmaceutical Sciences, University of Cardiff, Cardiff, Wales CF10 3NB, UK.
  • Ucar A; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK; Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
  • Sims AH; Applied Bioinformatics of Cancer Group, Systems Medicine Building, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
  • Marangoni E; Laboratoire d'Investigation Préclinique, Institut Curie, 26 rue d'Ulm 75248 Paris Cedex 05, France.
  • Farnie G; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Landberg G; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
  • Howell SJ; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address: sacha.howell@christie.nhs.uk.
  • Clarke RB; Breast Cancer Now Research Unit, Institute of Cancer Sciences, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK. Electronic address: robert.clarke@manchester.ac.uk.
Cell Rep ; 12(12): 1968-77, 2015 Sep 29.
Article in En | MEDLINE | ID: mdl-26387946
Subject(s)
Antineoplastic Agents, Hormonal/pharmacology; Breast Neoplasms/genetics; Calcium-Binding Proteins/metabolism; Drug Resistance, Neoplasm/drug effects; Gene Expression Regulation, Neoplastic; Intercellular Signaling Peptides and Proteins/metabolism; Membrane Proteins/metabolism; Neoplastic Stem Cells/metabolism; Proto-Oncogene Proteins/metabolism; Receptors, Notch/metabolism; Aldehyde Dehydrogenase 1 Family; Animals; Basic Helix-Loop-Helix Transcription Factors/antagonists & inhibitors; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Benzazepines/pharmacology; Breast Neoplasms/drug therapy; Breast Neoplasms/mortality; Breast Neoplasms/pathology; Calcium-Binding Proteins/genetics; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/genetics; Cell Cycle Proteins/metabolism; Cell Line, Tumor; Cell Proliferation/drug effects; Drug Resistance, Neoplasm/genetics; Estradiol/analogs & derivatives; Estradiol/pharmacology; Estrogen Receptor Antagonists/pharmacology; Female; Fulvestrant; Homeodomain Proteins/antagonists & inhibitors; Homeodomain Proteins/genetics; Homeodomain Proteins/metabolism; Humans; Intercellular Signaling Peptides and Proteins/genetics; Isoenzymes/antagonists & inhibitors; Isoenzymes/genetics; Isoenzymes/metabolism; Jagged-1 Protein; Membrane Proteins/genetics; Mice; Neoplastic Stem Cells/drug effects; Neoplastic Stem Cells/pathology; Proto-Oncogene Proteins/antagonists & inhibitors; Proto-Oncogene Proteins/genetics; Receptor, Notch4; Receptors, Estrogen/genetics; Receptors, Estrogen/metabolism; Receptors, Notch/antagonists & inhibitors; Receptors, Notch/genetics; Retinal Dehydrogenase/antagonists & inhibitors; Retinal Dehydrogenase/genetics; Retinal Dehydrogenase/metabolism; Serrate-Jagged Proteins; Signal Transduction; Survival Analysis; Tamoxifen/pharmacology; Transcription Factor HES-1; Xenograft Model Antitumor Assays
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Breast Neoplasms / Calcium-Binding Proteins / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins / Drug Resistance, Neoplasm / Antineoplastic Agents, Hormonal / Intercellular Signaling Peptides and Proteins / Receptors, Notch / Membrane Proteins Type of study: Prognostic_studies Language: En Journal: Cell Rep Year: 2015 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Breast Neoplasms / Calcium-Binding Proteins / Gene Expression Regulation, Neoplastic / Proto-Oncogene Proteins / Drug Resistance, Neoplasm / Antineoplastic Agents, Hormonal / Intercellular Signaling Peptides and Proteins / Receptors, Notch / Membrane Proteins Type of study: Prognostic_studies Language: En Journal: Cell Rep Year: 2015 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos