FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.
Elife
; 4: e09811, 2015 Sep 29.
Article
in En
| MEDLINE
| ID: mdl-26418745
Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of human cancers, including non-small cell lung cancer and neuroblastoma (Hallberg and Palmer, 2013). Vertebrate ALK has been considered to be an orphan receptor and the identity of the ALK ligand(s) is a critical issue. Here we show that FAM150A and FAM150B are potent ligands for human ALK that bind to the extracellular domain of ALK and in addition to activation of wild-type ALK are able to drive 'superactivation' of activated ALK mutants from neuroblastoma. In conclusion, our data show that ALK is robustly activated by the FAM150A/B ligands and provide an opportunity to develop ALK-targeted therapies in situations where ALK is overexpressed/activated or mutated in the context of the full length receptor.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cytokines
/
Receptor Protein-Tyrosine Kinases
/
Enzyme Activation
Limits:
Humans
Language:
En
Journal:
Elife
Year:
2015
Document type:
Article
Affiliation country:
Suecia
Country of publication:
Reino Unido