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The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer.
Yonesaka, Kimio; Kudo, Keita; Nishida, Satomi; Takahama, Takayuki; Iwasa, Tsutomu; Yoshida, Takeshi; Tanaka, Kaoru; Takeda, Masayuki; Kaneda, Hiroyasu; Okamoto, Isamu; Nishio, Kazuto; Nakagawa, Kazuhiko.
Affiliation
  • Yonesaka K; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Kudo K; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Nishida S; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Takahama T; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Iwasa T; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Yoshida T; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Tanaka K; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Takeda M; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Kaneda H; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
  • Okamoto I; Center for Clinical and Translational Research, Kyushu University, Fukuoka, Kyushu, Japan.
  • Nishio K; Department of Genome Biology, Kinki University School of Medicine, Osaka, Japan.
  • Nakagawa K; Department of Medical Oncology, Kinki University School of Medicine, Osaka, Japan.
Oncotarget ; 6(32): 33602-11, 2015 Oct 20.
Article in En | MEDLINE | ID: mdl-26418897
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Carcinoma, Non-Small-Cell Lung / Receptor, ErbB-3 / Neuregulin-1 / Protein Kinase Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncotarget Year: 2015 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / Carcinoma, Non-Small-Cell Lung / Receptor, ErbB-3 / Neuregulin-1 / Protein Kinase Inhibitors / Lung Neoplasms Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Oncotarget Year: 2015 Document type: Article Affiliation country: Japón Country of publication: Estados Unidos