Phenotypic screening: the future of antibody discovery.
Drug Discov Today
; 21(1): 150-156, 2016 Jan.
Article
in En
| MEDLINE
| ID: mdl-26440132
ABSTRACT
Most antibody therapeutics have been isolated from high throughput target-based screening. However, as the number of validated targets diminishes and the target space becomes increasingly competitive, alternative strategies, such as phenotypic screening, are gaining momentum. Here, we review successful phenotypic screens, including those used to isolate antibodies against cancer and infectious agents. We also consider exciting advances in the expression and phenotypic screening of antibody repertoires in single cell autocrine systems. As technologies continue to develop, we believe that antibody phenotypic screening will increase further in popularity and has the potential to provide the next generation of therapeutic antibodies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies
Type of study:
Diagnostic_studies
/
Screening_studies
Limits:
Animals
/
Humans
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2016
Document type:
Article
Affiliation country:
Reino Unido