Feasibility of a Modified Biopsy Needle for Irreversible Electroporation Ablation and Periprocedural Tissue Sampling.
Technol Cancer Res Treat
; 15(6): 749-758, 2016 12.
Article
in En
| MEDLINE
| ID: mdl-26443800
ABSTRACT
OBJECTIVES:
To test the feasibility of modified biopsy needles as probes for irreversible electroporation ablation and periprocedural biopsy.METHODS:
Core biopsy needles of 16-G/9-cm were customized to serve as experimental ablation probes. Computed tomography-guided percutaneous irreversible electroporation was performed in in vivo porcine kidneys with pairs of experimental (n = 10) or standard probes (n = 10) using a single parameter set (1667 V/cm, ninety 100 µs pulses). Two biopsy samples were taken immediately following ablation using the experimental probes (n = 20). Ablation outcomes were compared using computed tomography, simulation, and histology. Biopsy and necropsy histology were compared.RESULTS:
Simulation-suggested ablations with experimental probes were smaller than that with standard electrodes (455.23 vs 543.16 mm2), although both exhibited similar shape. Computed tomography (standard 556 ± 61 mm2, experimental 515 ± 67 mm2; P = .25) and histology (standard 313 ± 77 mm2, experimental 275 ± 75 mm2; P = .29) indicated ablations with experimental probes were not significantly different from the standard. Histopathology indicated similar morphological changes in both groups. Biopsies from the ablation zone yielded at least 1 core with sufficient tissue for analysis (11 of the 20).CONCLUSIONS:
A combined probe for irreversible electroporation ablation and periprocedural tissue sampling from the ablation zone is feasible. Ablation outcomes are comparable to those of standard electrodes.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biopsy, Needle
/
Electroporation
/
Ablation Techniques
Limits:
Animals
Language:
En
Journal:
Technol Cancer Res Treat
Journal subject:
NEOPLASIAS
/
TERAPEUTICA
Year:
2016
Document type:
Article
Affiliation country:
Estados Unidos